According to the scientific literature, 98% of megaprojects in the construction sector suffer from cost overruns of more than 30%. This is due to several reasons, the most important of which are productivity issues. Off-site manufacturing in construction is one solution to increase productivity, but there is a current lack of studies linking it to the concept of design for manufacturing and assembly. The combination of BIM and off-site construction (OSC) could maximize their benefits to the construction industry and their applications are highly recommended to improve construction efficiency. The aim of this project is to help improving construction efficiency with the integration of OSM in Construction, BIM, and Digital Fabrication. The specific objective is to develop a BIM-enabled Decision Support System (BeDSS) for the use of digital fabrication in off-site manufacturing in construction for multifunctional components or parts of buildings. This research will also identify the key success factors to improve construction efficiency through OSM. The contribution to the body of knowledge will be the outcome of this research including an in-depth discussion on main trends in off-site construction, research gaps, and recommendations for near-future perspectives in off-site construction.